Game Boy

Dr. Mario was Nintendo's great attempt to create a second handheld puzzle phenomenon after Tetris.

Its medical, virus-clearing theme gave Nintendo a puzzle identity entirely different from falling blocks, and it became one of the system's most recognisable early competitive puzzle games. The UK edition is interesting to collectors because Dr. Mario went through several British print variants, so regional and print-run differences matter more here than one might expect.

More from the Museum's Journal: Dr. Mario: Nintendo's Plumber Puts On a Lab Coat.